Endocrine Disruptors

Endocrine Disruptors


Endocrine disruptors have been linked to various cancers, damage to the immune system and many reproductive health problems.

Some have been termed “gender-benders” as they are thought to damage reproductive organs and fertility, or alter the sex ratio of offspring, as has been observed in many species (humans included).

The main evidence for these effects comes from studies of wildlife or of laboratory animals that scientists have exposed to known amounts of suspected endocrine disruptors.

More recent research has connected specific chemicals to health impacts in human populations.

Concerns about endocrine disruptors have led to calls for tighter regulations or bans of these chemicals. Some scientists and industry bodies argue however that there is no solid evidence of a real problem.

Endocrine disruptors are thought to interfere with hormones, the natural chemical messengers that regulate the functions of our cells and organs.

Some, for instance, are thought to disrupt the male sex hormone androgen or mimic the female sex hormone estrogen.

This poses special risks to young boys and has been linked to genital deformities, testicular cancer and reduced sperm counts.

People are most at risk if they are exposed to endocrine disruptors in the womb or in early childhood when their bodies are still developing.

There are hundreds of known or suspected endocrine disruptors. They include animal hormones, plant chemicals, pesticides, and compounds including phthalates and PBDEs from industrial and consumer products.

Some are persistent organic pollutants (POPs), which have spread globally and increased in concentration up the food chain.

This means people can be exposed through the food they eat, especially if their diet is rich in fatty meat or fish, as the chemicals accumulate most readily in fat.


Some endocrine disruptors are or could be controlled by international treaties such as the Stockholm Convention and the Rotterdam Convention.

In addition, some governments have banned or controlled the use of some of these chemicals, however, most are unregulated, especially in developing nations.

Some endocrine disruptors can persist in the environment by accumulating in soils and marine or river sediments. Such sites can sometimes be cleaned up – or remediated – but this can be very costly and take a long time.

Methods for remediation include using high-tech equipment and using biological processes, such as plants or microbes that absorb pollutants and break them down into safe compounds.

For alternatives to specific endocrine disruptors, please see the individual toolkit pages listed below.

Reporting Tips

The vast majority of the tens of thousands of synthetic chemicals in everyday use are untested and unregulated.

Journalists reporting on suspected endocrine disruptors need a good understanding of scientific evidence and ability to communicate risk.

To help journalists tackle these stories, RTNDF published a Journalist’s Resource Guide, Environmental Hormones: Threats to Health & Reproduction?

A big challenge for reporters is the difficulty of saying for certain that a health effect is definitely due to exposure to a particular chemical. Proving that link is almost impossible, even if the chemical is a known endocrine dispruptor.

Journalists should also be aware of national and international laws controlling these substances.

The websites of the Stockholm Convention or the Rotterdam Convention are good sources of information on current and proposed controls, and contact details of relevant authorities in each nation.

Journalists need speak to these and other sources, including activists, health professionals and the chemical industry.

Many of the early studies about endocrine disruptors were summarised in a book called Our Stolen Future, whose authors’ website includes a page on media coverage of “myths and realities” about these chemicals.

Increasing awareness of these risks has led people to urge governments to adopt the precautionary principle, and regulate suspected endocrine disruptors even if there is not strong scientific evidence of harm.

Critics such as industry groups argue that this is unnecessary and point out that many naturally occuring chemicals in plants can also mimic human hormones.

For an analysis of how the media has covered these competing viewpoints, see this article.

SourceWatch includes listings of organisations that have commented publically on endocrine disruptors from both sides of the debate.

For story ideas, Environmental Health News has an archive of news stories about endocrine disruptors.

Case Study – Skewed sex ratios

Scientists have recently been reporting declines in male births worldwide, but this is particularly extreme than among the Aamjiwnaang First Nation community in Sarnia, Canada.

Research in the journal Environmental Health Perspectives in 2005 linked the skewed sex ratios with local petrochemical, polymer, and chemical plants.

It also showed that the community land was highly polluted. However, the researchers pointed out that is it hard to assess whether a single compound causes an adverse effect, adding that the community may have had multiple chemical exposures over the years.

The fact that some endocrine disruptors in the areas could be persistent organic pollutants that have travelled thousands of kilometres makes it even hard to say for sure what is causing the observed effects.

This story shows the challenges of reporting on endocrine disruptors and attributing observed effects to a specific source. To read how journalist Terri Hansen covered it, visit her blog.

Judith Graham, writing in the Chicago Tribune, wrote a more in-depth piece that showed how sex ratios are also changing elsewhere and included some alternative explanations.

For case studies of specific endocrine disruptors, see the toolkit pages on Bisphenol APBDEs and dioxin and PCBs.

Links to Other Toolkit Pages

Birth Defects
Bisphenol A
Dioxin and PCBs
PBDEs (Fire Retardants)
Persistent Organic Pollutants
Rotterdam Convention
Stockholm Convention

Further Reading

Chemicals, Health and Environment Monitoring Trust
European Commission – Endocrine Disrupters Website
Male Reproductive Health Disorders and the Potential Role of Exposure to Environmental Chemicals [PDF]
Stockholm Convention website
Rotterdam Convention website
World Health Organization – Global assessment of the state-of-the-science of endocrine disruptors

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